Dr. Dale was recruited to form the Neuroimaging Group within the Departments of Neurosciences and Radiology. He is highly skilled in the development and utilization of multimodality imaging technologies. Within both departments, Dr. Dale is the designated point person for integrating the various modes and methods of collecting imaging data, including functional MRI (fMRI), magnetoencephalography (MEG), electroencephalography (EEG), and optical imaging. His efforts are directed in three areas: continuing development and refinement of accurate and automated algorithms for evaluation subjects using multimodality approaches to data collection; statistical analysis of data; and conducting studies in animal models using optical imaging, high field fMRI, and electrophysiological recordings to enhance the interpretation of neuroimaging studies.
Correct modeling of EEG/MEG and optical signals requires an accurate segmentation of the tissues within the head. A major component of Dr. Dale's laboratory effort has been on developing accurate and automated algorithms for head segmentation. This work began while he was a graduate student at UCSD and continued with Dr. Bruce Fischl and Dr. Eric Halgren at Harvard Medical School. Efforts to date have resulted in the development of software tools that enable the automated segmentation of the entire head and brain, including the neocortex and subcortical structures, from MRI data. As Dr. Dale notes, “The task of automated structure segmentation of human brain anatomy has been a Holy Grail for years.” The Neuroimaging Group is currently involved in several clinical research studies, applying these methods to assessment of regional morphometric changes associated with normal and abnormal development, aging, and brain-related diseases such as schizophrenia, Alzheimer’s disease, and Huntington’s disease.
University of California, San Diego
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La Jolla, CA 92093-0841